Hepatocarcinoma is the third localization of cancer in Senegal. More than 90 per cent of these cases in Senegal are painfull locally advanced stages. Radiotherapy is helpful in palliative situation. Newer radiation techniques, such as stereotactic body radiation therapy (SBRT) help reducing the radiation to nearby healthy tissues. This technique is not available in our institution. We report a case of 3D conformal total liver radiotherapy for locally advanced hepatocarcinoma.