High Performance Computing (HPC) has the potential to accelerate scientific discovery in Africa, but the continent faces several challenges that must be addressed to fully realize its potential. These challenges include limited access to HPC resources, limited technical expertise, limited data infrastructure, and funding constraints. However, there are also significant opportunities in accelerating scientific discovery through HPC in Africa, including collaborative research, enhanced research capabilities, improved data management, improved public health, production engineering and capacity building. By addressing these challenges and fully leveraging the power of HPC, African scientists can make important contributions to global scientific knowledge and innovation, driving further development in the continent and beyond.