Additional file 1:Figure S1. QQ-plot of P-values in (a) CARe, (b) FBPP and (c) WHI cohort. Figure S2. Proportion of local ancestries of (a) chromosome 1 and (b) chromosome 10. Figure S3. The recent selection signal (|iHS| > 2) on the epistatic regions on chromosome 1 in CARe cohort. Figure S4. The recent selection signal (|iHS| > 2) on the epistatic regions on chromosome 10 in CARe cohort. Figure S5. The tissue expression results of co-expressed genes on 53 tissue types by GTEx in FUMA. Figure S6. Heatmap of P-value of significantly co-expressed gene pairs located on epistatic regions on chromosome 1 in different tissues. Figure S7. Heatmap of P-value of significantly co-expressed gene pairs located on epistatic regions on chromosome 10 in different tissues. Figure S8. An example of admixture LD decay with genetic distance. Table S1. Correlations of Zscore among CARe, FBPP and WHI cohorts. Table S2. Number of crossover events between African and European chromosomes. Table S3. Comparison of co-expressed gene pairs between the epistatic regions and other regions not overlapped with the epistatic regions on chromosome 1 and chromosome 10. Table S4. Number of GWAS hits on the epistatic regions.