Additional file 1: Fig. S1. Pregnancy cohort and Study design. Table S1. Performance metrics of the different machine learning algorithms. Table S2. RMSE and Mean Abs Error in weeks obtained in three comparative models. Fig. S2. ROC analysis comparing discriminatory ability of four models evaluated. Table S3. Newborn screening metabolomic analytes estimated. Table S4A. Description of the model. Table S4B. Description of the model.