Entrepreneurship education (EE) was included in Tanzania’s secondary school curriculum to alleviate poverty and create jobs. Entrepreneurship education content and approaches must be carefully selected and structured to further its effectiveness in addressing these goals. Global research shows notable patterns, or what can be considered ‘best practices’ in this regard, which can be used for comparison purposes. Therefore, the current investigation aimed to evaluate if, and to what extent, the EE included in the Tanzanian secondary school curriculum adheres to international best practices for structuring EE. Informed by such an evaluation, recommendations can be made to strengthen EE in this curriculum. A two-phased sequential mixed-methods investigation was conducted. Qualitative curriculum analysis, followed by a quantitative survey of 135 secondary school teachers, provided detailed data about structuring EE in the Tanzanian school curriculum. The data analysis showed the Tanzanian school curriculum could support effective EE; however, curriculum content and teacher education should be improved to advance EE in the country.