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Analysis code for Wastewater surveillance predicts Mpox outbreak dynamics in a resource-limited urban setting

Domain:

healthcare

Record type:

software
Creator:
NsaKab
Publisher:
Zenodo
Host:avatar

Wastewater-Based Epidemiological Surveillance of Mpox Virus (MPXV) in Kampala Metropolitan Area, Uganda — February to September 2025

This repository contains the statistical analysis pipeline for a wastewater-based epidemiological (WBE) surveillance study of Mpox virus across four treatment facilities in the Kampala metropolitan area over 32 consecutive weeks (Epidemiological Weeks 6–37, 2025).

Study Overview

Objective: Evaluate whether MPXV genomic copies detected in wastewater (WW) correlate with and lead clinical mpox positivity rates in Kampala, Uganda, and quantify the early-warning potential of wastewater surveillance across four sites.

The code performs descriptive statistics, Shapiro–Wilk normality testing, Wilcoxon tests with Holm correction, Quenouille-adjusted effective sample size estimation, Spearman correlation, ±4-week lead–lag analysis with BH correction, Theil–Sen regression with bootstrap confidence intervals, and exploratory GEE modelling.

All figures and supplementary tables are generated programmatically to ensure full reproducibility.

Visit

doi.org

Languages

Ndasa

Tags

Mpox (monkeypox)Wastewater/microbiologyWastewater-Based Epidemiological MonitoringWastewater/statistics & numerical data

Licenses

info:eu-repo/semantics/openAccessCreative Commons Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/legalcode

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