Disease risk score and receiver operating characteristic curves based on transcript signatures of Berry et al. [25] for TB versus LTBI (A/B/C) and TB versus OD (D/E/F) applied to the combined training and test cohorts in HIV-uninfected (HIV−) and HIV-infected (HIV+) (A/D), HIV− (B/E), and HIV+ (C/F) cohorts (Table 4 for sensitivities, specificities, and area under the curve). Classification cut-offs: (A) 1,847.73; (B) 1,777.65; (C) 1,898.97; (D) 172.12; (E) 170.30; (F) 173.70.