BRCA1/2 sequencing in Moroccan Breast cancer.

Breast cancer is one of the most common malignancies and the leading cause of death among women worldwide. About 20% of breast cancers are hereditary. With the emergence of genetic testing, BRCA1/2 gene profiling was strongly recommended for women with a family history or early age onset of BC. The assessment of BRCA1/2 mutation carriers in familial breast cancer has been proved to be valuable not only in the perspective of prevention and early detection of related cancers but also it has implications in implementation of personalized medicine and chemoprevention of recurrence. This study is an attempt to fill some gaps and gain more information regarding the molecular germline profile of BRCA1/2 in the Moroccan population. The knowledge about the contribution of BRCA1 and BRCA2 mutations in Moroccan breast cancer will lead to better understanding of genetic risk factors of this disease in Morocco