Comparative Evaluation of Patient Satisfaction in Natural and Programmed IVF Cycles: A Randomized Clinical Trial.
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Background: While in vitro fertilization (IVF) outcomes are traditionally assessed using biological and clinical indicators, patient satisfaction is increasingly recognized as a key component of quality, patient-centered fertility care. Differences in treatment burden and experience between natural and hormonally programmed IVF cycles may influence patient perceptions and acceptance of care.
Objective: To compare patient satisfaction between natural IVF cycles and combined oral contraceptive pill (OCP) programmed IVF cycles in a randomized clinical trial.
Methods: This single-center, open-label randomized controlled trial enrolled 86 women undergoing IVF at a tertiary fertility center in Nigeria. Participants were randomly assigned in a 1:1 ratio to either a natural cycle IVF group (n = 43) or an OCP-programmed cycle IVF group (n = 43). Both groups underwent controlled ovarian stimulation using a standardized short GnRH agonist protocol. Patient satisfaction with ovarian stimulation was assessed at the end of the treatment cycle using a structured Likert-scale questionnaire. Data were analyzed on an intention-to-treat basis, with statistical significance set at p < 0.05.
Results: The mean satisfaction score was slightly higher in the OCP-programmed group compared with the natural cycle group (2.02 ± 0.83 vs. 1.79 ± 0.94); however, this difference was not statistically significant (t = −1.216, p = 0.228). Overall, participants in both groups reported favorable satisfaction levels with ovarian stimulation. Sociodemographic variables, including ethnicity and religion, were comparable between groups, although differences were observed in occupation and marital status.
Conclusion: Patient satisfaction with ovarian stimulation is comparable between natural and OCP-programmed IVF cycles. These findings support the use of either approach based on clinical indications, logistical considerations, and patient preference, without concern for reduced patient satisfaction