(A) Individual ancestry proportions (red = European; yellow = Indigenous American, blue = African). (B) Histogram comparing the Indigenous American ancestry in the Mexico City cohort (Mex1) and Los Angeles cohort (Mex2). (C) Principal component analysis of the Mexican individuals from Mexico City and Los Angeles, CA. Red and blue circles indicate the location of the HapMap CEU and YRI individuals, respectively. Gray points represent admixed individuals; virtual genomes, MexAMR (yellow), MexEUR (blue) and MexEUR (red) are projected to the PC plot. (D) Admixing times estimated by the number of ancestry blocks. The number of European (vs non-European) ancestry blocks is plotted against European ancestry (red); analogously, the numbers of Indigenous American (vs non-Indigenous American) blocks are plotted against the Indigenous American ancestry (yellow). Each curve represents the expected number of such blocks for a specific admixing time (in generations).