Despite efforts to contain the spread of COVID-19, Addis Ababa, the country’s COVID-19 epicenter, will experience a sharp increase in the number of cases and death rate. While poor public adherence to COVID-19 precautionary practices will remain evident, factors associated with it will not be well studied. We will aim to assess the level of practice of COVID-19 precautions and associated factors. This will be a hospital-based cross-sectional study at Saint Paul’s Hospital Millennium Medical College, a tertiary teaching hospital in Addis Ababa, Ethiopia. We will use a structured questionnaire to conduct face-to-face exit interviews with clients visiting the hospital. Systematic random sampling will be employed to recruit study participants. Binary and multivariable logistic regressions will be implemented to examine factors associated with precautionary practices. Statistical significance will be declared at p-value <0.05. The Crude Odds Ratio (COR) and Adjusted Odds Ratio (AOR) will be reported with a 95% confidence interval.