COVID-19 Vaccination Concerns: Perspectives of Youths in a Developing Nation's Context

International audience Background: Vaccine programmes' success lies in the acceptability and understanding of vaccine concerns among diverse population groups. This study investigates the covid-19 vaccination concerns among Nigerian youths. Methods: We conducted a cross-sectional study of 631 youths (343 females and 270 males) between 15-44 years who were randomly recruited online and offline from the six geo-political regions of Nigeria. The questionnaire was administered between 10 February and 15 March 2021. SPSS (Chi-square and Cramer's V Statistic) was used to determine the association (p<0.05)between covid-19 vaccination concerns and participants' demographic characteristics. Results: Among the 12 identified covid-19 vaccination concerns, side-effects (p=0.037), not necessary (p=0.007), negative reaction to vaccines (p=0.026) and assumed non-exposure to covid-19 patients (p=0.004),, were statistically associated with gender. For age, efficacy doubt (p=0.023), political/economic construct (p=0.023), family disapproval (p=0.018), and non-exposure to covid-19 patients (p=0.000) were statistically significant. Efficacy doubt (p=0.029) and the vaccine is a hoax (p=0.020) were associated with marital status. Side effect (p=0.182), a mere human experiment (p=0.777), doubt on efficacy (p=0.305), not necessary (p=0.457), political/economic construct (p=0.673), negative reaction to vaccine (p=0.162), and the vaccine may not be affordable (p=0.506) were not associated with the occupation. For the level of education, side effects (p=0.140), a mere human experiment (p=0.580), efficacy doubt (p=0.243), and negative reaction to the vaccine (p=0.386). Conclusion: Amongst youths in developing nations, especially in institutions of learning, health promotion and vaccine advocacy strategies should be intensified. The strategies should incorporate reinstating trust in vaccine efficacy and education and target youths and their family health decision-makers.