Covid-19 Vaccine Acceptance in Ethiopia: A Systematic Review and Meta-Analysis

Abstract Background The Coronavirus Disease-2019 pandemic impacted the everyday lives of the global population whereas a considerable proportion of people are offhand of taking the vaccine. And hence this study assessed the overall level of vaccine acceptance in Ethiopia. Methods Database search for articles was made systematically across Google Scholar, Web of Science, Science Direct, Hinari, EMBASE, Boolean operator, and PubMed. Selection, screening, reviewing, and data extraction was made by two reviewers independently using a Microsoft Excel spreadsheet. The modified Newcastle-Ottawa Scale(NOS) and the Joanna Briggs Institute prevalence critical appraisal tools were used to assess the quality of evidence. All studies conducted in Ethiopia, reporting vaccine acceptance were incorporated. The extracted data were imported into the Comprehensive meta-analysis version3.0 for further analysis. Publication bias was checked by using Beggs and Eggers tests. Heterogeneity was checked by Higgins’s method. A random-effects meta-analysis model with a 95% confidence interval was computed to estimate the pooled effect size (prevalence). Furthermore, subgroup analysis based on the study area and sample size was done