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Cross-ancestry portability of canonical Mendelian randomization estimates — analysis code

Domain:

healthcare

Record type:

software
Creator:
Far
Publisher:
Zenodo
Host:avatar

Pre-registered audit of ten canonical Mendelian randomization (MR) exposure–outcome pairs (LDL → CAD, urate → gout, BMI → T2D, BP → stroke, Lp(a) → CAVS, HbA1c → T2D, lipid → stroke-subtype) across European, East Asian, and African ancestries. Primary estimator is MR-APSS; sensitivity panel includes IVW, MR-Egger, weighted median, weighted mode, MR-PRESSO, Radial-MR, multivariable lipid MR, and colocalisation (coloc.abf). Repository contains the full analysis pipeline (R + Python) sufficient to reproduce every quantitative result, table, and figure in the accompanying manuscript. Manuscript-preparation and submission scripts are intentionally excluded.

Visit

doi.org

Tags

Mendelian randomizationcross-ancestrypolygenic risk scoresMR-APSScolocalisationequity of evidencepre-registrationreproducibilityGWAShorizontal pleiotropy

Licenses

info:eu-repo/semantics/openAccessMIT Licensehttps://opensource.org/licenses/MIT

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