Background: This is a hospital based descriptive study conduct at Al Mubarak Cytopathology lab (Khartoum State) during the period from November to December 2020. Aim: The study aimed to identify the common cytopathological patterns of lymphadenopathy among Sudanese patients. Materials and Methods: Fifty patients presenting with peripheral lymphadenopathy were included in the study, their ages ranging from 4 to 84years, with a mean age of 39.22 years old. Demographic characteristics, clinical manifestations and FNA materials were prospectively obtained. Results: FNA was performed in 92 cases (100%). There were no technical complications. All cases confirmed adequacy of specimen. Overall, FNA demonstrated 34 (37%) benign lesions and 58 (63%) malignant diagnosis. The benign lesions were reactive lymphoid hyperplasia 25 (31.5%) followed by Tuberculous lymphadenitis 5 (5.4%). Malignant cases were diagnosed with Metastatic carcinoma 43 (42.4%), Non- Hodgkin’s lymphoma 10 (1.8%) and Hodgkin`s lymphoma 5 (9.9%). Conclusion: Metastatic carcinoma and reactive hyperplasia were the most common causes of lymph node lesions among lymphadenopathy Sudanese patients.