Data from: A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection

Asymptomatic ebolavirus infection could greatly influence transmission dynamics, but there is little consensus on how frequently it occurs or even if it exists. This paper summarises the available evidence on seroprevalence of Ebola, Sudan and Bundibugyo virus IgG in people without known ebolavirus disease. Through systematic review, we identified 51 studies with seroprevalence results in sera collected from 1961 to 2016. We tabulated findings by study population, contact, assay, antigen and positivity threshold used, and present seroprevalence point estimates and 95% confidence intervals. We classified sampled populations in three groups: those with household or known case-contact; those living in outbreak or epidemic areas but without reported case-contact; and those living in areas with no recorded cases of ebolavirus disease. We performed meta-analysis only in the known case-contact group since this is the only group with comparable exposures between studies. Eight contact studies fitted our inclusion criteria, giving an overall estimate of seroprevalence in contacts with no reported symptoms of 3.3% (95% CI 2.4-4.4, p<0.001), but with substantial heterogeneity. Findings from a systematic review of ebolavirus serology in subjects without known ebola virus diseaseThe dataset contains findings and information from 51 seroprevelance studies performed from on samples collected from 1961 to 2016. These investigated 84 exposure-defined subgroups of subjects reported to have had no symptoms of EVD during the outbreak period, or to have come from populations with no known outbreaks. The data covers more than 44,000 people. The dataset records the sample locations, exposure type, numbers investigated, number/% considered positive and the cut-off used to define positivity. The data comes from a systematic review of published papers: DOI/PMCID?PMIDs are recorded. Information on antigens tested, any validation work and other notes are in the ReadMe file, as are explanations of the variablesScidata EV Asymp Serology Dataset 061216.csvScidata EV Asymp Full Findings Table 061216Table 1: detailed breakdown of the study populations, test methods and results.