This study examined the HRQoL and associated factors among informal caregivers of older persons in an urban community in Oyo State, Nigeria. A cross-sectional study was conducted among 554 informal caregivers of urban community-dwelling older persons. Data were obtained using a semi-structured, interviewer-administered questionnaire. Data collected include physical functioning, physical health, energy/fatigue, emotional well-being, social functioning, pain, and general health perceptions.