The aim of this paper is to investigate and compare the determinants of Internet use by senior generation among Tunisian and Romanian context that have different economic and cultural backgrounds. Research data were taken from a survey carried out on 400 online senior citizens (200 Tunisian and 200 Romanian). Data were analyzed by using confirmatory factor analysis and multiple regression analysis. Results show that cognitive age, Familial Loneliness and Social Anxiety have a significant effect on internet use for surfing and seeking information and not for buying. It was also found in the Romania sample the most determinant of internet use was Familial loneliness, while, social Anxiety was the most determinant of internet use, in the Tunisian sample.