Sustainable agribusiness initiatives are essential for environmental conservation, economic growth, and food security. However, cassava processors in rural Nigeria face barriers such as financial constraints, limited knowledge, and socio-economic challenges. This study examines factors influencing participation in sustainable agribusiness initiatives among cassava processors in Ido Local Government Area, South-West Nigeria. A structured questionnaire was used to collect data from 101 respondents, selected from a total population of 298 cassava processors across eight major processing sites. Data were analyzed using descriptive and inferential statistics, including multiple regression analysis. Findings reveal that 65.3% of respondents were aged 41-60 years, 64.4% had secondary education, and 45.5% had 16-25 years of experience. Monthly income was relatively modest, with 51.4% earning between ₦31,000 and ₦50,000. Awareness of sustainable agribusiness initiatives was high (mean = 3.94/5), and participation levels were also significant (mean = 2.52/3). However, financial constraints (mean = 3.56/5) and limited access to reliable information (mean = 2.30/5) hindered engagement. Regression analysis (R² = 0.826, F = 54.458, p < 0.05) identified awareness (β = 0.555, p < 0.001) as the strongest predictor of participation, while gender (β = -0.119, p = 0.019), education (β = -0.082, p < 0.001), and marital status (β = -0.109, p < 0.001) negatively influenced involvement. The study recommends targeted programs to improve awareness, provide financial support, and enhance capacity-building efforts, particularly for women and less-educated processors. Addressing these barriers will foster increased participation in sustainable agribusiness, contributing to economic empowerment and food security.