ECLiPSA: Protocol for a Realist Review of Pathways to Lung Cancer Diagnosis in LMICs

Lung cancer is a leading cause of cancer mortality worldwide. Delayed diagnosis is a significant contributor, particularly in low- and middle-income countries (LMICs). We are conducting a realist synthesis to explore the contextual factors that may influence pathways to diagnosis of lung cancer in LMICs. The review will generate CMO configurations explaining the function of lung cancer diagnostic pathways in these settings, with a particular focus on South Africa as a case context. Findings will inform strategies and policies to improve early diagnosis by addressing key contextual barriers and enhancing facilitators.