This systematic literature review aims to review economic evaluation literature relevant to the implementation of HPV vaccine in Nigeria.Cancers are emerging public health problems in developing countries like Nigeria accounting for over 85% of total global burden. Cervical Cancer is one of the most prevalent types of Cancer in Women globally; HPV infection is associated with cervical cancers. The most commonly associated subtypes are HPV-6, HPV-11, HPV-16, and HPV-18. Globally, several countries are implementing HPV vaccination programmes with the aim of preventing the development of cervical cancers in Women as young as 12 years of age. This study sought to investigate the economic evaluation of implementing HPV vaccination in Nigeria. Outcome of study is expected influence policy by advising relevant stakeholders on the socioeconomic impact of implementing HPV vaccination in Nigeria.