This study investigated the effectiveness of preservation strategies for indigenous knowledge management in public libraries across Southeastern Nigeria, specifically in Anambra, Imo, Abia, Ebonyi, and Enugu states. In the region, public libraries are essential for upholding and advancing indigenous traditions, bridging generational divides, and preserving cultural heritage against the challenges of globalization. Therefore, by utilizing a survey technique, the study employed a structured questionnaire to gather data on the perceived effectiveness of various preservation strategies, the challenges faced, and potential solutions. A random sampling technique was applied to select 130 librarians from public libraries in the region, with 117 (90%) completed questionnaires returned for analysis. The data were analyzed using mean scores to assess the effectiveness of preservation strategies and identify areas for improvement. The findings reveal that documentation and archiving using various media, digital archiving technology, and legal frameworks for intellectual property protection are considered highly effective strategies. Challenges such as inadequate technology, financial resources, and training were identified as significant barriers. The paper concludes that public libraries in Nigeria play a crucial role in safeguarding and sharing indigenous knowledge, bridging generational divides, and preserving cultural heritage in the face of globalization. Proposed solutions include investing in technological and financial resources, enhancing training programmes, and strengthening collaboration with Indigenous communities in order to improve preservation and ensure continued protection of indigenous knowledge in Southeastern Nigeria.