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Emerging INSTI Resistance in East African HIV-1 Under the 2019 WHO DTG Rollout

Domain:

healthcare

Record type:

paper
Creator:
Kel
Editor:
Cen
Publisher:
OSF
Host:avatar
Public HIV-1 drug-resistance surveillance derives per-drug Sierra levels from pol sequences without observed individual treatment history. Naive associations between mutation features and Sierra levels conflate causal drug pressure with subtype-specific polymorphism and non-random sampling. CausalPhylo v1 specifies a DAG-based identification framework and validates it on synthetic ground truth. This preregistration locks the real-data application against SAWA v0.1.0 in advance of running the analysis.

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