This paper presents the empirical modelling and investigation of solar panel tilt angle analysis. The aim is to determine the best suitable tilt angle for harvesting the optimal voltage from the solar panel system. Mono-crystalline solar panel with 220W was used to determine the output voltage from the solar panel, along with range of angles measured in degree (from 180 to 90) with responding time in hours (from 11:00 a.m. to 5:00 p.m.) towards the East and West hemispherical directions at Ekpoma. The experiment was carried out for duration of one year at Ambrose Alli University, Ekpoma (latitude 6.750N and longitude 6.070E).The highest output voltage from solar panel was obtained at 1.00 p.m. for the study location while the total output voltage (2745.32V) obtained from west hemisphere direction was higher than the voltage (2709.06V) obtained from the East hemispherical direction. The best tilt angle suitable for optimal voltage harvest is 10degree. Based on the empirical model deduced, it was observed that the output daily voltage at constant angle exhibits a polynomial distribution pattern with the least error value of 0.269.