The persistent underperformance of secondary school chemistry students in Nigeria’s public
examinations has prompted the need for evidence-based pedagogical innovations. This study
examined the differential effects of Process-Oriented Guided Inquiry Learning (POGIL), Blended
Learning, and Conventional Methods on the academic achievement of Senior Secondary II (SS II)
chemistry students in Delta State, Nigeria. A quasi-experimental pretest-posttest non-equivalent
control group design was adopted. The population comprised 29,409 SS II chemistry students
enrolled in government-owned secondary schools in Delta State for the 2024/2025 academic
session. A purposive, non-randomized sampling technique was used to select 204 students from
four secondary schools, distributed across four treatment groups: POGIL (n = 40), Blended
Learning (n = 48), Conventional Methods (n = 61), and Control/Revision (n = 55). Data were
collected using a Chemistry Achievement Test (CAT), whose reliability was established using
Cronbach’s Alpha. Mean scores, standard deviations, and one-way Analysis of Variance
(ANOVA) with Scheffe’s post-hoc test were used to analyse the data at a 0.05 significance level.
Results revealed that students taught via POGIL (X̅ = 48.13) and Blended Learning (X̅ = 46.92)
significantly outscored those in the Conventional Methods group (X̅ = 31.25), with the Control
group scoring the lowest (X̅ = 10.65). The ANOVA result was statistically significant (F =
3531.717, p ≤ .05). Scheffe’s post-hoc analysis confirmed that POGIL and Blended Learning were
equally effective and superior to Conventional Methods. It was recommended that chemistry
teachers adopt POGIL and Blended Learning strategies to enhance student achievement, while
educational policymakers should invest in digital infrastructure to sustain blended learning in
Nigerian secondary schools.