This study employed a quasi-experimental protocol to evaluate the efficacy of a culturally adapted, integrated Evidence-Based Counselling (EBC) framework (blending Cognitive-Behavioural Therapy and Mindfulness-Based Interventions) in reducing academic anxiety and exam stress among Senior Secondary School students in Anambra State, Nigeria. The high prevalence of anxiety (10.28% in adolescents), driven by severe socio-cultural pressures, necessitated empirically validated interventions. The study was guided by three research questions and two hypotheses were tested at the 0.05 level of significance. The population of the study comprised all Senior Secondary School students (SS1-SS3), typically aged 13 to 18, who were highly susceptible to academic stress in Anambra State. The Test Anxiety Inventory (TAI), Generalised Anxiety Disorder 7-item scale (GAD-7), Depression Anxiety Stress Scales 21-item version (DASS-21), and Academic Stress Scale (ASS) were the instruments used for data collection. The reliability of the instruments was confirmed using Cronbach's alpha, which yielded a coefficient of 0.81. Independent-samples t-tests at the immediate post-intervention phase revealed a highly significant reduction in test anxiety in the EBC group compared to the control group (p < 0.001), thereby rejecting the null hypothesis. Furthermore, the intervention achieved practically significant, moderate-to-large effect sizes (Cohen's D ≥ 0.61) across generalised anxiety and stress measures. The successful outcome validated the efficacy and cost-effectiveness of this culturally tailored EBC model for mass implementation in competitive Nigerian academic settings. This evidence mandated urgent policy revision, recommending the formal integration of EBC into the school timetable and mandatory, specialised skill mastery training for Anambra State school counsellors to address the systemic psychological barriers that impede educational success.