In Nigeria, the healthcare sector faces big challenges. Limited access to quality services and not enough resources are major issues. Using Artificial Intelligence (AI) could help improve healthcare. But understanding AI predictions is hard, especially in healthcare where transparency is crucial. This article looks at Explainable AI (XAI) to help with this problem in Nigeria. It talks about XAI techniques like feature importance examination, model-agnostic methods (e.g., LIME, SHAP), and interactive visualization tools. These tools can make AI models easier to understand and help with decision-making. A literature review was done to see how XAI can help healthcare in Nigeria. The review included scholarly articles, books, and reports on AI in Nigerian healthcare. We looked at methods from past XAI studies to find common approaches and best practices. XAI offers techniques that make AI models easier to understand in healthcare systems. These techniques include feature importance examination, model-agnostic methods, and interactive visualization tools. Case studies from Nigeria show how XAI is used in areas like disease diagnosis, treatment recommendations, and public health interventions. The findings show the importance of XAI in solving interpretability issues in healthcare AI, especially in places with limited resources like Nigeria. By explaining why AI makes certain predictions, XAI helps healthcare workers make better decisions for Nigerian patients. However, more research is needed to improve XAI techniques for Nigeria’s healthcare system. Policymakers and healthcare leaders should focus on using XAI-enabled systems to drive innovation and improve healthcare outcomes in Nigeria.