Fire safety in biomedical research institutes requires integrated architectural, engineering, and operational strategies due to the presence of hazardous materials, complex laboratory systems, and critical research assets. However, fire-safety provisions in many developing-country research facilities remain reactive and insufficiently integrated into architectural planning. This study develops a fire-safety design framework for biomedical research institutes in Abuja, Nigeria, based on an assessment of existing research facilities. A mixed-methods approach combining case-study audits and questionnaire surveys was adopted. Three federally established research facilities were assessed using seven fire-safety design strategies, while 103 facility managers and laboratory personnel participated in the survey. Findings revealed poor fire-safety integration, with overall compliance scores of 34%, 37%, and 51% (mean = 41%). Major deficiencies included inadequate fire compartmentation, incomplete detection and suppression systems, absence of HVAC fire-safety integration, poor hazardous-material management, and weak institutional preparedness. Survey results confirmed low awareness of regulatory requirements, emergency procedures, and fire-safety management practices. The study proposes the Safe Science Fire-Safety Design Framework, integrating passive protection, active systems, building services, hazardous-material control, and safety management. The framework provides a context-specific approach for improving the fire resilience of biomedical research institutes in Nigeria and similar developing-country settings