This study investigates the role of forensic auditing in detecting and preventing fraud in Rwandan hospitals, focusing on financial integrity and healthcare governance from 2008 to 2012. A qualitative research design was employed, involving case studies, interviews with healthcare administrators and forensic experts, and analysis of financial reports. Statistical analysis revealed a significant increase in fraud detection post-implementation of forensic auditing mechanisms, with surprise audits improving detection by 46.7% (p < 0.05) and audit software increasing efficiency by 25% (p < 0.05). The findings highlighted billing fraud as the most prevalent issue, rising from 5 to 15 cases annually, and financial losses peaking at RWF 150 million in 2012. Integrating forensic auditing with governance reforms achieved a 40% reduction in financial losses (p < 0.05). Recommendations include institutionalizing forensic auditing, enhancing governance frameworks, and adopting advanced audit technologies. This research underscores the transformative potential of forensic auditing in strengthening healthcare systems.