Genetic associations with alcohol drinking initiation and cessation in sub-Saharan African and African ancestry populations

Abstract Alcohol misuse is a major global health concern with significant genetic contributions, yet studies in African populations remain limited. We conducted genome-wide association meta-analyses for alcohol drinking initiation and cessation across multiple cohorts comprising individuals from sub-Saharan Africa (N = 20,936) and those with African ancestry from UK Biobank (N = 7,726). Our analyses identified two genome-wide significant loci associated with drinking cessation ( FYB2 and FTO regions) and several suggestive associations overlapping with genes implicated in alcohol metabolism, behavioral traits, and neurodevelopment. These findings provide insights into the genetic architecture of alcohol use behaviors in diverse African populations. By focusing on alcohol drinking initiation and cessation phenotypes, this study complements prior research on alcohol dependence and consumption, highlighting genetic factors influencing vulnerability and resilience. Our results underscore the importance of including diverse ancestries in genetic studies to enhance understanding of alcohol-related behaviors and inform future investigations into prevention and intervention strategies.