Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population
Domain:
healthcareRecord type:
paper
Creator:
AndDarSerAle
Publisher:
Nat
Host:
Significance
The search for genetic variants associated with resistance or susceptibility to HIV/AIDS already yielded insights that allowed developing therapeutics that contribute to dramatic reduction in AIDS-related comorbidities. Unfortunately, nearly all studies focused on European-descent populations, even though most infections happen in Africa. In this genome-wide association study we explored the genetic background of several hundred individuals from Botswana in search of associations with HIV infection. We discovered several genetic variant associations in genes implicated in HIV/AIDS pathogenesis. We also confirmed several associations reported in previous research. This study provides valuable data on the influence of human genetic variation on HIV-1C infection and pathogenesis in southern Africa, a region with the world’s largest number of HIV-1 infections.
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