Genomic characterization of Dengue virus circulation in Ethiopia
Domain:
healthcareRecord type:
dataset
Creator:
AduHouGerEdu
Publisher:
ope
Host:
ABSTRACT
In Ethiopia, dengue virus (DENV) infections have been reported in several regions, however, little is known about the circulating genetic diversity. Here, we conducted clinical surveillance for DENV during the 2023 nationwide outbreak and sequenced DENV whole genomes for the first time in Ethiopia. We enrolled patients at three sentinel hospital sites. Using RT-PCR, we screened serum samples for three arboviruses followed by serotyping and sequencing for DENV-positive samples (10.4% of samples). We detected two DENV serotypes (DENV1 and DENV3). Phylogenetic analysis identified one transmission cluster of DENV1 (genotype III major lineage A), and two clusters of DENV3 (genotype III major lineage B). The first showed close evolutionary relationship to the 2023 Italian outbreak and the second cluster to Indian isolates. Co-circulation of DENV1 and DENV3 in some regions of Ethiopia highlights the potential for severe dengue. Intensified surveillance and coordinated public health response are needed to address the threat of severe dengue outbreaks.
Similar
Genomic Characterization and Serotype Distribution of Dengue Virus Circulating in Pakistan During 2024Genomic investigation reveals local persistence and regional circulation of dengue virus associated with recent outbreaks in KenyaGenomic characterization of Crimean-Congo hemorrhagic fever virus in Hyalomma ticks from Cameroon highlights circulation of the Africa 3 lineageGenomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018Dengue and Chikungunya virus circulation in Cameroon and Gabon: molecular evidence among symptomatic individualsEarly genomic detection of the Cosmopolitan Genotype of Dengue Virus 2 in Angola, 2018