bethrahn128/DTG-uptake

Patient-level uptake of DTG-based ART in Southern Africa in R. # Assessing DTG uptake among those newly initating ART and those switching to DTG ART. This repository shares the R coding files used to produce the output included in the following: ### IWHOD 2024 conference abstract and poster presentation: > Trends in dolutegravir uptake by sex in Southern Africa. Zaniewski E, Fox MP, Fatti G, Muula GK, Mbewe S, Romo M, de Waal R, Egger M, Rohner E. IWHOD 2024 ## Data This analysis included HIV cohort data from The International epidemiology Databases to Evaluate AIDS Southern Africa collaboration (iedea-sa.org), which collects de-identified patient-level data from participating cohorts in Lesotho, Malawi, Mozambique, South Africa, Zambia and Zimbabwe. ## Methods Quantified uptake of DTG-based ART among six countries in Southern Africa between 2018-2023 by looking at DTG uptake among two cohorts of patients: 1) **Initiating cohort:** comprised of treatment-naïve individuals newly starting ART - calculated percentage initiating DTG-based ART aggregated tri-monthly. 2) **Switching cohort:** treatment-experienced individuals on non-DTG-based ART - calculated cumulative incidence of switching to DTG-based ART using Kaplan-Meier and Aalen-Johansen methods; the latter method considered the competing risk events of death, transfer out and loss to follow-up. Statistical analyses performed in R Statistical Software (v4.3.3; R Core Team 2022) with RStudio (version 2023.12.1). ## Coding files in R Figure in abstract Figure in poster ## Abstract Figure ## Poster Figure [![CC BY-NC-SA 4.0][cc-by-nc-sa-image]][cc-by-nc-sa] [cc-by-nc-sa]: creativecommons.org [cc-by-nc-sa-image]: licensebuttons.net