ersilia-os/impm-schisto-signature-reversal

Exploratory analysis with IMPM, Cameroon, investigating omics signature reversal strategies for schistosomiasis. # Schistosomiasis signature reversal analysis This repository contains exploratory work carried out as a collaboration between the IMPM (Yaoundé, Cameroon) and Ersilia. The goal of this project is to investigate molecular signatures and potential reversal strategies for schistosomiasis. ## Summary We obtained several transcriptomics signatures corresponding to schistosomiasis patients in Cameroon. We use signature reversal strategies to identify drugs or potential perturbations capable of correcting these signatures to a normal-like state. Below is a list of the relevant meetings related to this project: - Meeting on 2026/01/22: First analysis on L2S2. It contains a brief quantification of the signatures provided, and a quick query to the L2S2 signature reversal server. It contains natural products data analysis as well. ## Tracking details 1. Analysis of the transcriptomics data 2. ## About the Ersilia Open Source Initiative The Ersilia Open Source Initiative is a tech-nonprofit organization fueling sustainable research in the Global South. Ersilia's main asset is the Ersilia Model Hub, an open-source repository of AI/ML models for antimicrobial drug discovery.