lifang12506010004/api_agility_simulation

Simulation for agile API manufacturing in Africa # Agile API Manufacturing in Africa: Production Scheduling Simulation This repository contains the simulation model and data processing code for the Matters Arising article: > Li, F. (2026). Matters Arising: "Not so fast: what production scheduling reveals about agile API manufacturing in Africa". Arising from Sagandira, C. R. *Nature Communications Medicine* 5, 127 (2025). The code simulates a multi‑product active pharmaceutical ingredient (API) facility under African conditions, comparing agile (flexible) vs. dedicated line configurations. Key outputs include fill rates, safety inventory requirements, and break‑even analysis. ## Repository structure ├── README.md ├── requirements.txt ├── LICENSE ├── replication_guide.md ├── simulation_model.py ├── run_simulations.py ├── plot_results.py ├── bic_cluster_adjust.py ├── utils.py ├── preprocess.py ├── notebooks/ │ └── demo.ipynb ├── tests/ │ └── test_simulation.py ├── data/ │ ├── WHO_procurement_2018_2023.csv │ ├── correlation_table.csv │ ├── facility_params.csv │ ├── country_demand.csv │ ├── economic_params.csv │ └── results/ │ └── simulation_outputs.csv ## Requirements Install dependencies: ```bash pip install -r requirements.txt Quick start Run the baseline simulation: python run_simulations.py Reproduce Figure 1 (break‑even plot): python plot_results.py License MIT License (see LICENSE file). Citation If you use this code, please cite the Matters Arising article (see the manuscript for details). --- ### `requirements.txt` ```txt simpy==4.0.2 numpy==1.26.0 pandas==2.1.0 matplotlib==3.8.0 scipy==1.11.0 seaborn==0.13.0 jupyter==1.0.0 pytest==7.4.0