Maherjerry/grc_analysis

The GRC Project is a Malaria Drug Resistance Surveillance to assess molecular markers of chloroquine resistance of Plasmodium falciparum samples from multiple African countries. # GRC Sierra Leone & Guinea Analysis Manuscript ### **Genetic Report Cards (GRCs)** The Genetic Report Cards (GRCs) are comprehensive datasets that provide detailed genetic information about malaria parasites. These datasets are derived from blood samples collected from malaria-infected individuals. The samples undergo a series of processes: 1. **Sample Collection:** Blood samples are collected from individuals infected with malaria. 2. **Parasite Isolation:** The malaria parasites are isolated from the blood samples. 3. **DNA Extraction:** The DNA of the malaria parasites is extracted. 4. **Genome Sequencing:** The extracted DNA is sequenced to determine the genetic makeup of the parasites. 5. **Data Compilation:** The genetic data is compiled into the GRCs, which include various genetic markers, mutations, and other relevant information. The GRCs provide valuable insights into the genetic diversity, drug resistance, and transmission patterns of malaria parasites, aiding in the development of effective control strategies. ### **Purpose of the Analysis** The primary objectives of this analysis are: * **Prevalence and Diversity:** To understand the prevalence and genetic diversity of malaria parasites in different regions. * **Drug Resistance:** To identify and characterize drug resistance profiles of malaria strains. * **Geographical Mapping:** To map the spread and relatedness of malaria strains across various locations. * **Genetic Relationships:** To explore the genetic relationships between samples using IBS matrices and related plots. ### **Dataset Overview** We have Genetic Report Cards from various countries like **The Gambia**, **Sierra Leone**, **Guinea**, **Cameroon**, **Ethiopia**, **Nigeria** etc. Below is an example of some columns present in the dataset: * **Sample Internal ID:** Unique identifier for each sample. * **ENA Accession Number:** Identifier for the sample in the European Nucleotide Archive. * **Sample External ID:** Another iden …