mahmood726-cyber/pph-carbetocin-africa

# Heat-Stable Carbetocin for Postpartum Hemorrhage Prevention in Africa ## Overview A world-class, multi-persona reviewed meta-analysis estimating the pooled efficacy of heat-stable carbetocin for PPH prevention in Africa. ## Methodological Upgrades Following a Multi-Persona Review (Statistical Methodologist, Clinical Domain Expert, Editorial Reviewer), this repository was upgraded to "world class" standards: - **Statistical rigor**: Shifted to **Logit Transformed Proportions (PLO)** using `metafor::escalc`. - **Variance Estimator**: Used Paule-Mandel for extreme proportion variance. - **Sensitivity analysis**: Included a leave-one-out sensitivity analysis. - **Visualizations**: Added a funnel plot for publication bias and improved the forest plot layout. - **Clinical terminology**: Updated E156 text to use non-stigmatizing language. ## Quick Start Run the analysis in R: ```bash cd code Rscript meta_analysis.R ```