GSEA of the THP1r2<i>Mtb</i>-induced signature using transcriptome data from human tuberculosis patients.
Domain:
healthcareRecord type:
Traning set: all the donors, which were defined as PTB, LTB or healthy, were recruited from London, UK. Test set: all the donors were from London UK. Validation set: all the donors were from Cape Town, South Africa. Test set_seperated: purified neutrophils, monocytes, CD4+ T cells, and CD8+ T cells from both PTB and healthy controls. Longitudinal study: PTB patients before drug treatment, 2 months after drug treatment, and 12 months after drug treatment.
2Group-group contrasted and ranked by LIMMA-based method.
3(+) NES for positive correlation, (−) NES for negative correlation.
4Significance of correlation, an FDR of 0.05 or lower was accepted as statistically significant for NES (“Positive” or “Negative”), otherwise “Null”. See Figures S7,S8,S9 for plot graph of each group comparison. See Figure S10 for CPP-SOM graph of expression data of each donor.