This research intended to analyze the current usage of health research evidence in health planning, determinants, and readiness to use knowledge translation tools among planning teams in Tanzania. Specifically, the study aims to 1) analyze the current usage of health research evidence among planning team members at the regional and council levels, 2) analyze the capability for the use of health research evidence among planning team members at regional and council levels, 3) analyze the opportunities for the use of health research evidence among health planning members at regional and council levels, 4) to identify the motivations for the use of health research evidence among health planning team members at regional and council levels, and 5) to assess the readiness of the planning team members on the use of knowledge translation tools. The study employed an exploratory mixed-method study design. It was conducted in nine (9) regions and eighteen (18) Councils of Tanzania Mainland involving the health planning team members.