The distribution of HLA genes and haplotype frequencies was studied in a population of 119 Sarakole West Africans. The absence of HLA‐B15, the rarity of HLA‐A10, B12 and B17 and the relatively high frequency of HLA‐A2 and B5 were noted. The presence of a Da 6 gene in the African populations is confirmed. The main gametic associations were Aw19‐Bw35 and Aw23‐B5.