Accurate mapping of land use and land cover (LULC) is crucial for various applications such as urban planning, environmental management, and sustainable development, particularly in rapidly growing urban areas. African cities such as Yaoundé, Cameroon, are particularly affected by this rapid and often uncontrolled urban growth with complex spatio-temporal dynamics. Effective modeling of LULC indicators in such areas requires robust algorithms for high-resolution images segmentation and classification, as well as reliable data with great spatio-temporal distributions. Among the most suitable data sources for these types of studies, Sentinel-2 image time series, thanks to their high spatial (10 m) and temporal (5 days) resolution, are a valuable source of data for this task. However, for an effective LULC modeling purpose in such dynamic areas, many challenges remain, including spectral confusion between certain classes, seasonal variability, and spatial heterogeneity. This study proposes a hybrid deep learning architecture combining U-Net and Convolutional Long Short-Term Memory (ConvLSTM) layers, allowing the spatial structures and temporal dynamics of the Sentinel-2 series to be exploited jointly. Applied to the Yaoundé region (Cameroon) over the period 2018–2025, the hybrid model significantly outperforms the U-Net and ConvLSTM models alone. It achieves a macro-average F1 score of 0.893, an accuracy of 0.912, and an average IoU of 0.811 on the test set. These segmentation performances reached up to 0.948, 0.953, and 0.910 for precision, F1-score, and IoU, respectively, on the built-up areas class. Moreover, despite its better performance, in terms of complexity, the figures confirm that the hybrid does not significantly penalize evaluation speed. These results demonstrate the relevance of jointly integrating space and time for robust LULC classification from multi-temporal satellite images.