The Upper Senegal River Basin is a strategic water resource system supporting agriculture, hydropower generation, and essential ecosystem services in West Africa. However, a comprehensive understanding of its hydrological dynamics remains constrained by the limited availability of in situ hydroclimatic observations. This study applies the Soil and Water Assessment Tool (SWAT) to simulate hydrological processes in the basin, with a particular emphasis on the influence of precipitation data sources on model performance and uncertainty. Hydrological simulations were conducted at six representative gauging stations (Bakel, Kayes, Gourbassy, Oualia, Bafing Makana, and Daka Saidou) over the period 1983–2021, using a combination of ground-based observations, satellite precipitation products, and reanalysis datasets (ERA5, MERRA-2, PERSIANN, and CHIRPS). Model calibration demonstrated satisfactory performance, with Nash–Sutcliffe Efficiency (NSE) values reaching up to 0.74 at upstream stations, while reduced performance was observed downstream. Validation results showed a moderate decline in model efficiency, highlighting the sensitivity of SWAT outputs to precipitation inputs and data uncertainty. The comparative analysis of precipitation datasets reveals substantial variability in simulated streamflow and water balance components, underscoring the importance of precipitation data selection in data-scarce regions. These findings highlight the need for robust, multi-source hydroclimatic data integration to improve hydrological modelling reliability and support informed water resource management decisions.Keywords: Upper Senegal River, SWAT, Hydrological modelling, Precipitation uncertainty; Satellite rainfall; Reanalysis data.