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Identifying Darwinian Selection Acting on Different Human APOL1 Variants among Diverse African Populations

Record type:

paper

Creator:

WenPriFelLau

Publisher:

Elsevier BV

Host:

Visit

Licenses

https://www.elsevier.com/tdm/userlicense/1.0/https://www.elsevier.com/open-access/userlicense/1.0/

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Identifying signatures of positive selection in human populations from North Africa

Abstract Because of its location, North Africa (NA) has witnessed continuous demographic movements

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression

BACKGROUND: During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction

No evidence for association between APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

International audience

No evidence for association with APOL1 kidney disease risk alleles and Human African Trypanosomiasis in two Ugandan populations

Abstract Background:

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious all

Preeclampsia in mice carrying fetuses with APOL1 risk variants

Abstract African-American women have a maternal mortality rate