Logo Lanfrica
  • Home
  • Atlas
  • Insights
  • Docs
  • Sign in

© 2026 Lanfrica. All rights reserved. All copyrights of the resources shown on the Lanfrica website belong to the original copyright holders, unless explicitly stated otherwise.

Impaired cerebrovascular reactivity in pediatric sickle cell disease using diffuse correlation spectroscopy

Domain:

healthcare

Record type:

paper
Creator:
KylMarTisLaB
Publisher:
Opt
Host:
Cerebrovascular reactivity (CVR), defined as the ability of cerebral vasculature to dilate in response to a vasodilatory stimulus, is an integral mechanism in brain homeostasis that is thought to be impaired in sickle cell disease (SCD). This study used diffuse correlation spectroscopy and a simple breath-hold stimulus to quantify CVR non-invasively in a cohort of 12 children with SCD and 14 controls. Median [interquartile range] CVR was significantly decreased in SCD compared to controls (2.03 [1.31, 2.44] versus 3.49 [3.00, 4.11] %/mmHg, p = 0.028). These results suggest DCS may provide a feasible means to routinely monitor CVR impairments in pediatric SCD.

Visit

doi.org

Licenses

https://doi.org/10.1364/OA_License_v2#VOR-OAhttps://opg.optica.org/policies/opg-tdm-policy.json

Similar

Establishing Sickle Cell Diagnostics and Characterizing a Pediatric Sickle Cell Disease Cohort in MalawiPediatric Sickle Cell Disease in Sudan: Complications and ManagementCerebral Infarcts and Cerebrovascular Disease in Neurologically Intact Tanzanian Children with Sickle Cell AnaemiaCorrelation Between Soluble Endothelial Adhesion Molecules and Nitric Oxide Metabolites in Sickle Cell DiseaseEtienneNtumba/-GWAS-of-Sickle-Cell-Disease-in-Tanzania-Using-RegenieDoes deteriorating oxidative defence and impaired γ-glutamyl cycle drive pathophysiology in individuals with sickle cell disease?

Establishing Sickle Cell Diagnostics and Characterizing a Pediatric Sickle Cell Disease Cohort in Malawi

Abstract Sickle cell disease (SCD) is highly prevalent in sub-Saharan Africa; howev

Pediatric Sickle Cell Disease in Sudan: Complications and Management

Background. Sickle cell disease (SCD) is a life-threatening genetic disorder due to the formation of

Cerebral Infarcts and Cerebrovascular Disease in Neurologically Intact Tanzanian Children with Sickle Cell Anaemia

Abstract Introduction: Children and adolescents with sickle cell a

Correlation Between Soluble Endothelial Adhesion Molecules and Nitric Oxide Metabolites in Sickle Cell Disease

Nitric Oxide (NO) and soluble adhesion molecules are promising biomarkers, which predict endothelial

EtienneNtumba/-GWAS-of-Sickle-Cell-Disease-in-Tanzania-Using-Regenie

# **Genome-Wide Association Study (GWAS) of Sickle Cell Disease in Tanzania Using Regenie** ## **1.

Does deteriorating oxidative defence and impaired γ-glutamyl cycle drive pathophysiology in individuals with sickle cell disease?

ickle cell disease (SCD) is a global health crisis, affecting two-thirds of the children born in Afr