The sustainability of mineral development increasingly depends on early understanding of ore processability and environmental behavior rather than ore grade alone. This study presents a data-driven framework that integrates multi-physics geophysical data (magnetic, electrical resistivity, induced polarization, and electromagnetic) with machine-learning models to predict metallurgical and environmental indicators at the exploration stage. Geophysical attributes were derived from datasets covering 187 mining locations within a Precambrian basement terrain in southwestern Nigeria. Proxy indicators for mineral liberation, recovery potential, comminution behavior, and environmental risk were developed based on established geophysical–mineralogical relationships. Supervised machine-learning models (random forest and gradient boosting) were trained and evaluated using cross-validation. The models achieved classification accuracies ranging between approximately 75% and 82% across key indicator classes, demonstrating that geophysical signatures—particularly chargeability and resistivity contrasts—provide meaningful predictive insight into subsurface processability and environmental response. However, predictions remain proxy-based and do not replace direct metallurgical testing. The framework offers a scalable approach for integrating processability and environmental considerations into early-stage mineral exploration, especially in data-scarce and artisanal mining contexts.