Significance
The parasitic weed
Striga
is the greatest biological constraint to production of many crops in Africa and parts of Asia. Genetic control is the most feasible means of crop protection from this pest. We report on identification of a gene regulating
Striga
resistance in sorghum and the associated change in strigolactone chemistry. Knowing this gene and its various natural alleles, sorghum breeders can design markers within it to facilitate its transfer into improved varieties providing farmers effective control of
Striga
in infested fields. The gene could also be used to potentially improve
Striga
resistance through genome editing in crops such as maize that evolved away from
Striga
, and hence have a paucity of
Striga
resistance genes.