Digital technologies present opportunities for growth and competitiveness, although its adoption is constrained by infrastructural gaps and systemic challenges. This study investigates the impact of digital transformation on entrepreneurial activities in Nigeria characterized with a low-infrastructure economy. A descriptive survey design was employed, drawing data from 200 entrepreneurs across urban and rural areas using structured questionnaires. Descriptive and inferential statistics, such as Pearson correlation, regression, and t-tests, were applied for analysis. Correlation results show a significant positive relationship between digital transformation and entrepreneurial growth (r = .413*; p < .05). Infrastructural deficits such as poor internet, electricity and limited access to digital devices (β = -.217; t = 2.552; p < 0.05), (β = -.204; t = 2.151; p < 0.05) and (β = -.130; t = 1.419; p < 0.05 respectively) hinder the full technology adoption. Digital literacy emerged as a key determinant of effective technology use effectively (P-value .007 < 0.05). The study concludes by highlighting the need for stronger policy implementation, improved infrastructure, inclusive training, and gender-sensitive programs to advance digital entrepreneurship. Recommendations are provided to promote a more inclusive and digitally empowered entrepreneurial landscape in Nigeria.