New agents active against African swine fever virus

Domain:

healthcareagriculture

Record type:

paper

Creator:

A. S. C GB A

Publisher:

Ame

Host:

Actinobolin, atropine, carrageenan, megalomycin C, suramin, and tetracenomycin C were tested for their activity against African swine fever virus replication. Both viral inhibitory potency and cytotoxicity were investigated. Megalomycin C, suramin, atropine, and carrageenan exhibited significant activity. Megalomycin C was the most active of the four agents with respect to the concentration of compound that blocked the formation of infectious virus by 50%. Suramin was the next most active agent in this respect, but because of its lower cytotoxicity, it had the most favorable therapeutic index.

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doi.org

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https://journals.asm.org/non-commercial-tdm-license

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