This presentation, titled “Open Science in Africa: Practices, Partnerships, and the Power of Sharing,” explores how African researchers and institutions are embracing Open Science to advance equitable and transparent research ecosystems. The talk highlights key principles—open access, open data, open software, and open collaboration—supported by case studies from Open Science Community Nigeria (OSCN) and AfricArXiv, alongside partnerships with INOSC, Open Life Science, and Africa CDC. It concludes with actionable steps for early-career scientists and insights into how Open Science is accelerating innovation through bioinformatics and emerging technologies across Africa.