This article examines the intricate legal dynamics of employee inventions in Cameroon. Under Annex I of the Organisation Africaine de la Propriété Intellectuelle patent regime, patent rights generally belong to employers when inventions are made during employment or with employer resources. This rule applies unless a contract provides otherwise. However, uncertainties remain regarding inventors’ rights and entitlement to compensation. The crux of the matter arises from ambiguous legal and contractual standards for defining employee inventions, attributing ownership, and ensuring fair remuneration, which undermines innovation incentives and generate disputes under both patent and labour law frameworks. The research question asks to what extent Cameroon’s patent and labour laws effectively protect employee inventors and balance employer entitlement with inventor remuneration and legal certainty. The hypothesis is that, although patent rights are contractually vested in employers, the existing regime inadequately protects employees’ economic and moral interests. The objective is to critically analyse the statutory, contractual, and jurisprudential mechanisms governing employee inventions and to recommend reforms that better align employer rights with inventor protections. Using a doctrinal legal methodology grounded in analysis of statutory instruments, OAPI provisions, collective agreements, case law and realities from African Regional Intellectual Property Organizatio (ARIPO), the study finds that while employers generally hold patent entitlement for employee inventions, employees’ rights to remuneration are narrowly defined and often contingent on internal employer policies or court intervention, leaving inventors with limited recourse. A major recommendation is to institute clearer statutory criteria for inventor remuneration, mandatory disclosure obligations, and enforceable compensation standards that reflect the commercial value of employee inventions and reduce reliance on ad hoc judicial determinations.